Tuco's Headquarters was a set of rooms above a cantina where Tuco Salamanca and his crew hung out.
Walt returned to the headquarters carrying a bag of crystal, he talked his way in. When Tuco asked him his name, Walt told him "Heisenberg". When Walt demanded $50,000 Tuco laughed and threatened him, Walt then threw one of the crystals of fulminated mercury to the floor. The ensuing explosion blew out the windows ("").
While discussing the manhunt for Tuco, Hank Schrader mentions that the DEA raided his headquarters along with his last known place of residence and arrested many of Tuco's lieutenants. However, Tuco himself was nowhere to be found. ("")
- in real life the location is a cafe called Java Joe's