Twelve hours before, a pants-less Walt and a black-eyed Jesse hire a nonplussed tow truck driver to pull the RV out of the ditch. Afterwards, the duo agree to end their criminal partnership as soon as they deal with the bodies of Emilio and Krazy-8. However, as Walt finally gets the engine of the decrepit RV to turn over, a sound alerts them to the fact that one of the "dead" men isn't dead.
The following morning, Walt wakes up naked on his bathroom floor. Walt's breakfast with his family is interrupted when Jesse calls his house posing as a telemarketer. When Walt finds privacy, Jesse demands that he out in dealing with Krazy-8 and disposing of Emilio's body. Walt tells Jesse that he can't come until after work. After Walt leaves for school, Skyler attempts to trace the call and hears Jesse's profane voicemail message, clueing her in to the fact that Walt was not talking to a telemarketer.
At school, Walt mishears a student asking about the "murder" instead of the "midterm". After class, he raids the chemistry supply closet for hydrofluoric acid. Meanwhile, Jesse hears more noise coming from the RV. When he looks out his window, he's stunned to see the vehicle's door wide open and Krazy-8 nowhere to be found.
Driving to Jesse's house in his Pontiac Aztek, Walt encounters an injured Krazy-8 stumbling down the middle of a suburban street. Walt waves him toward the car, but Krazy-8 recognizes his voice and tries to escape, only to knock himself out when he runs directly into a tree. Walt throws the unconscious drug dealer into his car.
At the White residence, Skyler conducts a web search for Jesse and comes across one of his social media profiles. Meanwhile, Walt brings the unconscious Krazy-8 back to Jesse's house, where they take him into the basement and secure him to a pole with a bicycle lock around his neck. Walt and Jesse then argue about what to do next. Their first priority is to dispose of Emilio's body and destroy the evidence. Walt suggests that they do so using hydrofluoric acid to break down the corpse. They also agree that they have to kill Krazy-8.
The duo toss a coin to see who will do what. Jesse wins the toss and chooses to dispose of Emilio's body, thus it falls upon Walt to kill Krazy-8. Walt instructs Jesse to buy a specific plastic bin so he can properly dispose of the body. However, upon visiting a home supply store, an impatient Jesse can't find one that's big enough for the body.
At Jesse's house, Walt, reluctant to kill Krazy-8, but ends up serving him a sandwich and providing makeshift toiletries instead. In order to relieve his stress, Walt smokes Jesse's marijuana. Jesse returns home and asks Walt how the murder went. Walt promises to take care of Krazy-8 tomorrow, then leaves to meet Skyler at a hospital for her sonogram. There, the couple learn that they are expecting a girl. Afterward, Skyler confronts Walt about his association with Jesse. In an attempt to hide the truth, Walt falsely confesses that Jesse is his pot dealer and asks his wife to "climb out of my ass".
Walt struggles to keep his secrets in check at work while Jesse retrieves Emilio's body from the RV. As he is dragging the body across the driveway, Skyler appears at his front gate. Jesse quickly positions himself so that she can't see the body. Skyler tells Jesse that her brother-in-law is a DEA agent and warns Jesse to stop selling pot to her husband. After she leaves, Jesse hauls Emilio's body up to his second-floor bathroom and, donning a gas mask, tries to dissolve the body in the bathtub with the hydrofluoric acid.
When Walt returns to Jesse's house, Jesse informs him of Skyler's visit and that he dissolved Emilio's body in the bathtub without having to buy the plastic container. In horror, Walt hurries into the hallway beneath the upstairs bathroom. Sizzling liquid can be seen seeping from the ceiling through the floor. Suddenly, the ceiling collapses followed by a cascade of gore, a mixture of hydrofluoric acid and Emilio's half-dissolved remains. Walt turns to Jesse and states the reason he asked for a plastic container: hydrofluoric acid eats through most materials except plastic. In the basement, Krazy-8 eyes a growing puddle of acidic fluid dripping onto the basement floor.
Out in the desert, at the site of their cook, two Native American children kick a ball around when one of them picks up Walt's discarded gas mask.
- This episode, along with Pilot, are the only two episodes that have a timeframe card in the beginning of the episode "i.e. "12 hours earlier". Many later episodes also begin in medias res but don't feature this text
- The title is a reference to the phrase "cat is out of the bag", meaning a secret has been disclosed.
- It's also a reference to part of a line from the 1957 film Sweet Smell of Success, in which a character reports that he resolved an issue. It means that Walt and Jesse capture Krazy-8 and lock him in the basement.
- J.J. Hunsecker: That means you've got a plan. Can you deliver?
Sidney Falco: Tonight, before you go to bed. The cat's in the bag and the bag's in the river.
- Jesse's home address is visible on his web profile: 9809 Margo Street.
- Jesse is seen watching The Three Stooges on TV while he was smoking a marijuana bong. Moe Howard had lung cancer just like Walt and died from it (although Moe was a heavy smoker, Walt isn't).
- The chemical decomposition of Emilio's body was tested on a special episode of Mythbusters, which guest-starred Vince Gilligan and Aaron Paul. The Mythbusters team immersed samples of ceramic, wood, plaster, metal, and raw pork (to simulate human flesh) in hydrofluoric acid, and declared the myth "busted"; while the acid quickly broke down the ceramic and the plaster, the other samples showed only mild corrosion, even after eight hours' immersion. The team also concluded that sulfuric acid, in conjunction with another chemical that accelerates the reaction, is the substance that Walt and Jesse should have used.
- Goof: Despite Krazy-8 offering Walt his money in sealed plastic bag in "", it is now in a brown paper bag which caused it to get wet from the spilled chemicals in the RV although the money getting wet explains why Walt removed it from a dryer at the end of "Pilot."
- The tree Krazy-8 runs into is 1 block down from the location used as Jesse's home, located at 16th and Silver Ave in Oxnard Park. Krazy-8 is actually running toward Pinkmans house.
- Jesse's house is located at 322 16th street in real life.
- "You're Movin' Me" by Clyde McPhatter (playing in Walt's car as he drives to Jesse's)
- "The Bike Lock" by Dave Porter (as Jesse fetches the bike lock from his garage)
- "Keep Ballin'" by Trump (playing on Jesse's MyShout page)
- "Unknown Track #4" by Unknown Artist (in the background while Jesse is at the hardware store)
- "Nine Years" by Ticklah (while Walter smokes pot)
- "The Hole" by Glenn Phillips (at the end of the episode when the kids find the gas mask)
- Walter: "Look. You skipped, clowned around or otherwise jerked off through every lecture I ever gave. As far as I'm concerned, your chemistry education is over."
- Jesse: "Oh okay, be a dick about it."
- ―Walter to Jesse.
- "Look, Skyler, I just haven’t quite been myself lately. I haven’t been myself lately, but I love you. Nothing about that has changed, and nothing ever will. So right now, what I need is for you to climb down out of my ass. Can you do that? Will you do that for me, honey? Will you please, just once, get off my ass. You know, I’d appreciate it. I really would."
- ―Walter calmly confronts Skyler to stop meddling in his affairs.