Next week Lydia’s Czech associates make a visit to the US, pressure Lydia to get Walt back into the meth-making business. Lydia, who always acts poorly under pressure, will try to bully Walt into getting back to business by having one of his kids killed (likely Walt Jr.). Lydia will most likely die as well in this episode, since in “Blood Money” she remarks that she is “in a box” and the next episode is called “Buried”.
Todd will make a return, he’ll die. Whenever Todd dies, his uncle & Nazi friends will target Walt since they’ve now met him.
Skyler will eventually be killed in a hostage-esque scenario in which Walt’s failure to act quickly will result in her death. This Walt-kills-Skyler theory goes hand in hand with the theory that Walt keeps traits of those that he kills (in the opening of season 5, he writes “52” with bacon and uses Skyler’s maiden name – Lambert – as his alias). His remaining children will go to Hank and Marie and Walt will flee town and go to New Hampshire because he may somehow be implicated in Skyler’s death. The only reason he comes back in the finale is to protect the new family from harm. He could be protecting them from a) the Czechs, b) Todd’s family, c) the Cartel, d) Gus’ connections in Chile, or ???
Jesse’s mental break will come to a head when, in the episode entitled “Confessions”, he discovers that Walt was responsible for Mike’s death, Brock’s near-death, and Jane’s death. He will become “rabid”, and in the following episode, entitled “Rabid Dog”, Walt will have to kill Jesse (the rabid dog) in the same way that Jesse had to kill Gale (the “Problem Dog”).
In the final episode, Walt will film a goodbye video to his remaining family exactly as he did in the pilot episode of the show. This time, the video will be to Holly, the only family member not mentioned in the original video, because this time she’ll be the only member of his immediate family left.